HORDB

ID: hor000811
Uniprot ID: Q5DW47
Protein name: Corazonin precursor-related peptide
Gene name: Crz
Organism: Apis mellifera (Honeybee)
Family: Corazonin family
Source: animal
Expression: In the adult brain, expressed in four neurons of the lateral protocerebrum project axons towards the retrocerebral complex.
Disease: NA
Comments: NA
Taxonomy: Apis (genus), Apini (tribe), Apinae (subfamily), Apidae (family), Apoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity; GO:0071858 corazonin receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0045823 positive regulation of heart contraction
GO CC: GO:0005576 extracellular region

Sequence: STSLEELANRNAIQSDNVFANCELQKLRLLLQGNINNQLFQTPCELLNFP
Length: 50(36-85)
Propeptide: MVNSQILILFILSLTITIVMCQTFTYSHGWTNGKRSTSLEELANRNAIQSDNVFANCELQKLRLLLQGNINNQLFQTPCELLNFPKRSFSENMINDHRQPAPTNNNY
Signal peptide: MVNSQILILFILSLTITIVMC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000811_AF2.pdb

hor000811_ESM.pdb

Mass:	655063	Formula:	C247H398N70O79S2
Absent amino acids:	HMWY	Common amino acids:	L
pI:	4.3	Basic residues:	3
Polar residues:	16	Hydrophobic residues:	19
Hydrophobicity:	-26.6	Boman Index:	-8656
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	105.4
Instability Index:	4711.4	Extinction Coefficient cystines:	125
Absorbance 280nm:	2.55